BioMarin genetic disorder drug meets main goal, shares jump
















(Reuters) – BioMarin Pharmaceutical Inc said a late-stage trial of its experimental genetic disorder drug met the main goal of improving patients’ walking ability when administered weekly, sending the company‘s shares up 25 percent in premarket trading.


The drug, called GALNS, however, did not show any improvement over a placebo when administered every other week.













The trial, named MOR-004, showed that weekly doses of the drug at 2 mg/kg improved the six-minute walk distance of patients by 22.5 meters over the placebo.


However, patients getting the same dose every other week did not show any meaningful or statistically significant change compared to the placebo.


The disorder – Mucopolysaccharidosis Type IVA (MPS IVA), or Morquio A Syndrome – is a rare, inherited disorder caused by the deficiency of a particular enzyme, leading to skeletal dysplasia, short stature and joint abnormalities.


The drug was also tested in another extension trial that showed its benefits continued to improve with further dosage, BioMarin said in a statement.


GALNS was generally well-tolerated and adverse events were similar to those seen in the trials of other enzyme replacement therapies. There were no deaths and no patients withdrew from the study due to adverse events.


BioMarin now plans to submit marketing applications for the drug, starting from the first quarter of 2013.


The company currently has four drugs in the market, two of which are for treating other metabolic disorders caused by the absence of certain enzymes.


Shares of the company closed at $ 37.41 on the Nasdaq on Friday, and were trading at $ 47 before markets opened on Monday. (Reporting by Esha Dey in Bangalore; Editing by Joyjeet Das)


Medications/Drugs News Headlines – Yahoo! News



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UK service sector growth ‘slows’

















Activity in the UK service sector grew at its slowest pace in almost two years in October, a survey has suggested.













The PMI services index from Markit/CIPS fell to 50.6 from 52.2 in September. Any score above 50 indicates growth.


Growth in new business eased, while employment in the sector fell for the second consecutive month, Markit said.


The figure was a reminder of the tough underlying economic conditions despite last month’s better-than-expected growth figures, it added.


Official figures showed that the UK economy grew by 1% between July and September, ending a nine-month long recession.


Bank meeting


“The latest UK services PMI data provide a warning to those who saw the strong growth in the GDP in the third quarter as symbolising the start of a strong and speedy economic recovery,” said Markit economist Andrew Harker.


“The expectation among firms is for activity to improve over the coming year, but the road to full economic recovery still looks to be a long one.”


Last week, the PMI survey for manufacturing indicated that the sector shrank in October for the sixth month in a row, while the survey of the construction sector found that while output was slightly higher, new work and employment shrank.


Analysts said the weaker-than-expected services PMI reading increased the possibility that the Bank of England might increase its programme of quantitative easing (QE), which has now reached a level of £375bn, when its monetary policy committee (MPC) meets later this week.


Under QE, the Bank buys government bonds, hoping to create beneficial knock-on effects for the economy.


“It does raise the risk of further QE from the Bank. On balance, though, we think it probably won’t, given the risk of inflation,” said George Buckley at Deutsche Bank.


“What it does tell us is that while there have been some mixed messages, more positive than negative, we’re not seeing a very fast recovery at all.”


Vicky Redwood, at Capital Economics, said: “The MPC pays a lot of attention to this survey and this Thursday’s meeting now looks an even closer call than before.


“Given the stronger near-term outlook for inflation, we think that the chances of more QE this week are just below 50-50.”


Separately, a report suggested that the UK would be the fastest-growing major economy in Europe in the next two years. The eurozone debt crisis would drag the bloc into a second year of recession, the Centre for Economics and Business Research (CEBR) said.


While the eurozone economy would contract by 0.4% in 2013, the UK economy would grow by 0.8%, the think tank predicted. In 2014, the CEBR said the eurozone would register growth of 0.4%, compared with the UK’s 1.4%.


BBC News – Business



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Brazil’s ‘pop-star priest’ gets mammoth new stage

























SAO PAULO (AP) — Brazil‘s “pop-star priest” is already packing in the crowds at the newly opened mammoth sanctuary that he built for his campaign to stem the exodus of faithful from the Roman Catholic Church in Latin America’s biggest nation.


Brazil still has more Catholics than any other country in the world, with about 65 percent of its 192 million people identifying themselves that way in the 2010 census. But that is down from 74 percent in 2000 and is the lowest since records began tracking religion 140 years ago.





















That’s where Father Marcelo Rossi‘s Mother of God sanctuary comes in. The not-yet-finished structure will seat 6,000 people and have standing room for 14,000 more, church leaders say. In addition, the grounds outside can hold 80,000 people who could watch Mass on outdoor video screens.


After the inaugural Mass on Friday attracted upward of 50,000 people, a beaming Rossi told reporters: “They couldn’t all fit in. There was a crowd that had to stand outside! That’s a sign we’re on the right path, and it’s this sanctuary.”


Similar numbers jammed into the huge church Saturday.


It’s a fitting stage for Rossi, a Latin Grammy-nominated singer who is known for tossing buckets of holy water on worshippers and performing rollicking Christian songs backed by a blasting live band during Mass.


The church sits on 323,000 square feet (30,000 square meters) of land. Church officials declined to confirm how big the actual building is, though local reports put it at 91,500 square feet (8,500 square meters). That would make it one of the world’s 10 biggest churches. A cross soaring 138 feet (42 meters) into the air is the focal point.


The Mother of God sanctuary is anything but traditional. Designed by noted Brazilian architect Ruy Ohtake, it has a wide-open layout giving it the feel of a warehouse. Concrete walls hold up a sloping blue roof that from the outside looks more like a basketball arena than a house of worship. With the church several years away from completion, white plastic chairs were in the place of pews for a lucky few thousand to grab a seat. The rest had to stand.


Rossi dismisses the idea his huge church is a response to the explosion of the evangelical Christian faith in Brazil. Rather, the priest seems to be battling what recent studies indicate is Catholicism’s biggest enemy: indifference.


While millions of Brazilian Catholics joined Pentecostal congregations in the 1990s, a study conducted last year by Brazil’s Getulio Vargas Foundation based on census data found that the Catholics leaving the church these days are mostly becoming nonreligious. Experts have said the trend of Brazilians deciding organized religion isn’t for them poses a more potent threat to Catholic leaders than losses to the Pentecostals.


Rossi chose to open his new church on the Brazilian holiday of Finados, the nation’s version of the Day of the Dead. “A day, a day that was dead, was transformed!” the priest told worshippers during the service, using his gold-plated microphone.


The “pop-star priest” is seen by Brazilian Catholicism as its biggest weapon against the lack of interest, and his new sanctuary adds to his tools of best-selling books and music recordings to keep worshippers interested in what many complain has become a staid institution.


There was nothing stale about his Mass on Friday.


Singing as loud as they could, waving white hankies and swaying with a rocking band, the 20,000 people who jammed into the Mother of God sanctuary hammed it up for TV cameras and shed tears down their cheeks as their superstar priest waved to them from the pulpit. An estimated 30,000 other people had gathered outside, where young boys climbed up into nearby trees trying to get a glimpse of the church grounds as they squinted over a sea of heads streaming out of the sanctuary.


“We have problems, everyone has problems,” worshipper Zuleima de Oliveira Sales said as she stood in the tightly packed sea of people under the soaring blue roof of the structure, her voice choking. “They don’t come to an end, but I have faith, I have faith in Our Lady.”


That’s the sort of belief the Catholic Church is counting on in Brazil and other developing nations. Leaders from the Vatican on down are looking to them as bulwarks against losses in Europe and the U.S., where sex abuse scandals have inspired many people to leave the church. About half of the world’s Catholics live in Latin America.


Pentecostalism was once seen as a major threat to Brazil’s Catholic Church. Pentecostal churches, many of them founded by U.S. evangelicals, saw their membership double to more than 12 percent of the country’s population over the 1990s, with about half of the congregants estimated to be former Catholics.


During the 1990s, Brazil’s economy suffered from hyperinflation and other woes, and Pentecostal churches aggressively recruited in the slums and poor outskirts of Brazil’s cities by offering nuts-and-bolts self-improvement advice as well as Christian ministry.


Since 2003, however, Pentecostal churches have seen growth slow. The percentage of Brazilians calling themselves Pentecostals edged up from 12.5 percent of the population to 13.3 percent.


Yet the Catholic Church has continued to lose parishioners, and church leaders have had little success so far in halting that trend.


Brazil was the first nation outside Europe that Pope Benedict XVI visited, during a five-day tour in 2007 largely aimed at stopping losses in Latin America. During the trip, the pope canonized Brazil’s first native-born saint.


Then Benedict announced last August during the church’s World Youth Day, which drew 1.5 million people to Spain, that the next version of the gathering would be held in Rio de Janeiro in 2013. The pope is expected to attend.


For now, Rossi hopes his big church will bring together tens of thousands of faithful for every Mass, giving new energy to the Catholic faith.


“People want big spaces. They want grand places for prayer,” he told the Globo TV network. “One candle illuminates, 10 candles illuminate — and 100,000 candles light up so much more.”


Latin America News Headlines – Yahoo! News



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Red Cross’ App Helps Sandy Victims

























App Name: Hurricane by The American Red Cross


Price: Free





















Available Platforms: iPhone, iPod Touch, iPad, (requires iOS 4.2 or later), and Android


What does this app do? Millions remained without power and the death toll in New York City topped 41 in the wake of Hurricane Sandy as of Friday morning, according to ABC News. Homes and businesses were wrecked as a result of the superstorm, with many people occupying shelters. Cleanup and recovery from Sandy will be slow and hard going for many. For those with power, or at least a charged mobile device, the Hurricane by American Red Cross app can help.


The app, although updated more than two months ago and, therefore, not exactly new, could not be more relevant than right now. Everything from its location-based alerts to its tips and checklists for planning for an emergency aims to prepare and assist those affected directly or indirectly by disaster.


The layout for this app is simple, with a string of informational buttons lining a row at the bottom. Tap on the “prepare” tab to peruse tips for planning ahead, such as what to put into an emergency kit or to learn about the evacuation plan for a particular community. The app will also alert you to warnings and storms based on locations you have selected and allow you to share those alerts with others through email. Select the “shelters” button to view and get directions to the open Red Cross shelters in your area.


On the upper-left-hand corner, the app displays a toolkit button. Select this icon to create a list of contacts as well as meeting points both within and outside of your neighborhood and share these with others in case of an emergency or evacuation.


Finally, and perhaps most importantly, tap on the “more” button, and then select “donate.” You can make a contribution to the Red Cross’s efforts via e-mail, iTunes or text.


Is it easy to set up? Download this free app and go for it.


Should I try it? This is an information-rich app with a lot of useful features. The best parts of it include the ability create a plan and share this with the people you love as well as the ability to send the “I’m safe” message via Twitter, Facebook and email.


Also Read
Wireless News Headlines – Yahoo! News



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AnnaLynne McCord to get “Scorned” With Billy Zane in new thriller

























LOS ANGELES (TheWrap.com) – AnnaLynne McCord is about to become a woman “Scorned.”


“90210″ star McCord has signed on for the revenge thriller “Scorned,” alongside “Titanic” star Billy Zane and Viva Bianca from Starz’s “Spartacus.”





















McCord and Zane will play Sadie and Kevin, a couple whose romantic weekend at a lake house takes a sideways turn when a text message from Sadie’s best friend (played by “Bianca”) to Kevin reveals a lurid love affair between the two, sending Sadie on a vengeance spree.


“Scorned” will be directed by Mark Jones, the creator and director of the beloved “Leprechaun” horror-movie series.


Jones likened the project to “sophisticated” thrillers such as “Fatal Attraction” and “Misery.”


“Having done horror with comedy, I wanted to delve into something more sophisticated along the lines of ‘Fatal Attraction’ and ‘Misery,’ and develop a multi-dimensional, twisted character in our lead villain (McCord), who I feel brings an original and incredibly unique take on her character,” Jones said.


Lightning Entertainment will handle international sales of the film, with Lightning’s Audrey Delaney and Marc Bienstock executive-producing.


Movies News Headlines – Yahoo! News



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Israel’s Neuronix offers new Alzheimer’s treatment

























TEL AVIV (Reuters) – Israel-based Neuronix, which has developed a non-invasive medical device to help to treat Alzheimer’s disease, expects the system to be approved by the U.S. Food & Drug Administration in late 2014.


The device, which combines electromagnetic stimulation with computer-based cognitive training, is already approved for use in Europe, Israel and several Asian countries. In Singapore it is approved for clinical trial use and the application for registration of the product is still under evaluation.





















“You stimulate the brain on a biological level as well as on a cognitive level,” Neuronix CEO Eyal Baror told Reuters, saying this double approach created longer-lasting benefits.


The device, which consists of a chair containing an electronic system and software in the back and a coil placed at the head, has been tested on mild to moderate Alzheimer’s patients who suffer from dementia but are not totally dependent.


The system is in trials at Harvard Medical School/Beth Israel Deaconess Medical Centre. Patients are treated for one hour a day, five days a week over six weeks.


“We see improvement lasting for 9-12 months and the good thing is that patients can return and undergo treatment again,” Baror said. “If out of 10 years the patients have left to live we can keep them at home in a relatively mild state of the disease for three, four, five years, it’s a lot.”


According to Alvaro Pascual-Leone, director of the hospital’s Berenson-Allen Centre for Non-invasive Brain Stimulation, brain stimulation – or transcranial magnetic stimulation – involves a very low current applied to a specific part of the brain and is approved by the FDA for treatment of a variety of ailments and diagnostic applications.


“The application in Alzheimer’s disease and in combination with cognitive training is novel,” Pascual-Leono said in a phone interview from Boston.


About 20 percent of patients experience a mild headache but there are no long-term negative effects, he said.


Pascual-Leone, who is principal investigator in the Harvard trial, said that of 12 patients in the study, six received the real treatment and all showed cognitive improvement. Their improvement was significantly more than the average seen in patients taking just medication, he said.


The study’s results will be submitted for publication in the coming weeks and a follow-up study on 30 patients is planned.


Neuronix received European approval several months ago and has installations in the UK and Germany. In Israel, a few dozen patients are being treated with the device.


The U.S. trials are expected to run till the end of 2013. Neuronix is also running a trial in Israel for pre-Alzheimer’s patients.


The company expects to sell half a dozen systems in the second half of 2012 and three dozen in 2013. In Israel, the treatment costs $ 6,000.


“Our target for becoming profitable is in parallel to entering the U.S. market around 2015,” Baror said.


Neuronix has raised $ 8 million from private individuals as well as in grants from the Israeli Chief Scientist’s Office and is exploring options to raise more money in the coming year, including the possibility of going public.


(This version of the October 24 story corrects paragraph two that company corrects to say that in Singapore, device is approved for clinical trial use and its application for registration of the product is under evaluation, not that device is approved for commercial use.)


(Reporting by Tova Cohen; editing by Stephen Nisbet)


Diseases/Conditions News Headlines – Yahoo! News



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Comet gift vouchers are suspended




























Comet customer: “It looks like a plague of locusts have been inside [the store] and cleaned the place out”



The administrators of the electrical retailer Comet have suspended the use of gift vouchers at the stores.


The shops have been open as usual over the weekend since administrators were called in on Friday.


The Comet website has returned in a slimmed down form, confirming store locations and answering questions about the administration.


There has been no sign of heavy discounting so far, but the website said a sale would be starting soon.


On the question of gift vouchers, it said: “The administrators are currently considering the position in relation to gift cards and gift vouchers and at this stage they cannot be used to pay for items.


“The administrators are reviewing this position urgently.”


Holders of gift vouchers would usually be considered as low priority creditors to a retailer going into administration, and would be unlikely to be able to use their vouchers.


The exception is when a chain is sold to new owners, who might decide to accept them as an act of goodwill to prevent the brand they have bought being tarnished.


The new website explained on its front page that administrators from Deloitte had been appointed.


Its question and answer section said that people who were waiting for items to be delivered that they had paid for would only be receiving those items if they were already in stock at a delivery centre.


“Where the item for an existing order is not currently in stock, this delivery cannot now be made,” it said.


BBC News – Business



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Syria army quits base on strategic Aleppo road

























BEIRUT (Reuters) – The Syrian army abandoned its last base near the northern town of Saraqeb after a fierce assault by rebels, further isolating the strategically important second city Aleppo from the capital.


But in a political setback to forces battling to topple President Bashar al-Assad, the United Nations said the rebels appeared to have committed a war crime after seizing the base.





















The opposition Syrian Observatory for Human Rights said on Friday government troops had retreated from a post northwest of Saraqeb, leaving the town and surrounding areas “completely outside the control of regime forces”.


It was not immediately possible to verify the reported army withdrawal. Authorities restrict journalists’ access in Syria and state media made no reference to Saraqeb.


The pullout followed coordinated rebel attacks on Thursday against three military posts around Saraqeb, 50 km (30 miles) southwest of Aleppo, in which 28 soldiers were killed.


Several were shown in video footage being shot after they had surrendered.


“The allegations are that these were soldiers who were no longer combatants. And therefore, at this point it looks very likely that this is a war crime, another one,” U.N. human rights spokesman Rupert Colville said in Geneva.


“Unfortunately this could be just the latest in a string of documented summary executions by opposition factions as well as by government forces and groups affiliated with them, such as the shabbiha (pro-government militia),” he said.


Video footage of the killings showed rebels berating the captured men, calling them “Assad’s dogs”, before firing round after round into their bodies as they lay on the ground.


Rights groups and the United Nations say rebels and forces loyal to President Bashar al-Assad have committed war crimes during the 19-month-old conflict. It began with protests against Assad and has spiraled into a civil war which has killed 32,000 people and threatens to drag in regional powers.


The mainly Sunni Muslim rebels are supported by Sunni states including Saudi Arabia, Qatar and neighboring Turkey. Shi’ite Iran remains the strongest regional supporter of Assad, who is from the Alawite faith which is an offshoot of Shi’ite Islam.


STRATEGIC BLOW


Saraqeb lies at the meeting point of Syria’s main north-south highway, linking Aleppo with Damascus, and another road connecting Aleppo to the Mediterranean port of Latakia.


With areas of rural Aleppo and border crossings to Turkey already under rebel control, the loss of Saraqeb would leave Aleppo city further cut off from Assad’s Damascus powerbase.


Any convoys using the highways from Damascus or the Mediterranean city of Latakia would be vulnerable to rebel attack. This would force the army to use smaller rural roads or send supplies on a dangerous route from Al-Raqqa in the east, according to the Observatory’s director, Rami Abdelrahman.


In response to the rebels’ territorial gains, Assad has stepped up air strikes against opposition strongholds, launching some of the heaviest raids so far against working class suburbs east of Damascus over the last week.


The bloodshed has continued unabated despite an attempted ceasefire, proposed by join U.N.-Arab League envoy Lakhdar Brahimi to mark last month’s Muslim holiday of Eid al-Adha.


In the latest in a string of fruitless international initiatives, China called on Thursday for a phased, region-by-region ceasefire and the setting up of a transitional governing body – an idea which opposition leaders hope to flesh out at a meeting in Qatar next week.


Veteran opposition leader Riad Seif has proposed a structure bringing together the rebel Free Syrian Army, regional military councils and other rebel forces alongside local civilian bodies and prominent opposition figures.


His plan, called the Syrian National Initiative, calls for four bodies to be established: the Initiative Body, including political groups, local councils, national figures and rebel forces; a Supreme Military Council; a Judicial Committee and a transitional government made up of technocrats.


The initiative has the support of Washington. U.S. Secretary of State Hillary Clinton called on Wednesday for an overhaul of the opposition, saying it was time to move beyond the troubled Syrian National Council.


The SNC has failed to win recognition as the legitimate representative of the Syrian people and Clinton said it was time to bring in “those on the front lines fighting and dying”.


(Additional reporting by Oliver Holmes in Beirut and Stephanie Nebehay in Geneva; Editing by Jon Boyle)


World News Headlines – Yahoo! News



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13 Gadgets to Prepare You for a Natural Disaster

























1. Wind-Up Radio


Radios may seem like primitive technology in the digital age, but they’re still very effective in relaying information during an emergency. The one pictured uses solar power, features a hand-crank for backup power and even includes a flashlight.


Click here to view this gallery.





















[More from Mashable: Yoink Crowdsources Aid After Sandy]


Earlier this week, Hurricane Sandy hit the East Coast of the United States as well as Caribbean countries, leaving tremendous disaster in its wake. People have gone without power for days, and the elderly and disabled — especially those in high-rise buildings — are unable to get the food and water they need.


[More from Mashable: NYC Marathon Canceled Amid Online Backlash]


Many of these people prepared for the storm, but due to Sandy’s magnitude, weren’t able to imagine its tragic aftermath.


We compiled a short list of tech essentials that could help you prepare for storms and natural disasters beyond Sandy, especially when a generator is either too expensive or isn’t plausible for your living situation. Of course, these items should be considered in addition to fundamental precautions and supplies, which include enough water and food to last at least three to seven days, a first aid kit, extra batteries and gasoline.


What kind of tech have you found useful in your disaster or emergency preparedness kit? Let us know in the comments.


[wp_scm_hurricane_sandy]


This story originally published on Mashable here.


Tech News Headlines – Yahoo! News



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Amy Winehouse wedding dress stolen: family foundation

























LONDON (Reuters) – Two dresses worn by late British singer Amy Winehouse have been stolen from her house, her family’s charitable foundation told Reuters on Thursday.


The two dresses were due to be auctioned as part of charity events later this year and next in London and New York to raise money for The Amy Winehouse Foundation, which funds a number of concerns including children’s hospices and drug counseling.





















One of the Back to Black singer’s stolen frocks was the dress she wore to marry Blake Fielder-Civil in 2007 and the other was a newsprint cocktail dress. Both were taken from a cupboard in her house after they had been catalogued alongside other items.


The foundation said the house had not been broken into and that a formal complaint to police was forthcoming.


The workers who catalogued the dresses after Winehouse’s death had packed them away in a cupboard and discovered two were missing when they later returned to check on the wardrobe.


“It’s got to be someone with access to the house,” a spokesman for the foundation said.


Amy’s father Mitch Winehouse was quoted in London’s Evening Standard newspaper as saying that he was “baffled” why thieves had not gone for her designer dresses.


“It’s sickening that someone would steal something in the knowledge of its sentimental value,” he said.


Amy Winehouse was found dead in her London home on July 23, 2011, at the age of 27 from what officials later determined was accidental alcohol poisoning. There were no illicit drugs in her system.


Fielder-Civil and Winehouse had a turbulent relationship, punctuated by violent fights and reports of heavy use of cocaine, heroin and ecstasy. They were married for about two years until 2009. He also served six months in prison stemming from an 2007 assault on a London pub landlord.


The “Rehab” singer’s ex-husband was put on life support in a British hospital in August after an apparent drink and drug binge.


Winehouse’s family have said that their daughter beat her drug dependency about three years before her death.


(Reporting by Paul Casciato, editing by Jill Serjeant and Patricia Reaney)


Music News Headlines – Yahoo! News



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